Europium complexes as probes for biological and materials applications
Item
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Title
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Europium complexes as probes for biological and materials applications
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Identifier
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d_2009_2013:5dcfbd262f78:10146
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identifier
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10444
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Creator
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Bensaid-Geyer, Laurence Fortunee,
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Contributor
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Lynn C. Francesconi
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Date
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2009
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Language
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English
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Publisher
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City University of New York.
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Subject
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Inorganic chemistry | Biochemistry
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Abstract
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Europium is a widely used lanthanide due to its emission in the visible region and its long lifetime. It is often complexed with ligands in order to serve different purposes in various domains: these complexes can be used as photostable biological probes but also as photoelectronic devices. This thesis interest will lie on both aspects. In chapter 2, we focused on europium phosphonates for targeting bone cancer. As we look at the adsorption of europium phosphonate to bone, possible scenario can take place: the complex can adsorb to the bone and/or the europium can transchelate from the ligand. If the europium transchelate, we looked at the possibility of a europium incorporation into the hydroxyapatite (HA) structure. We prove the presence of europium within the HA structure using various analytical and spectroscopic methods such as elemental analysis, X-ray diffraction (XRD), Infra-red (IR), luminescence studies, X-ray absorption fine structure (XAFS), and other spectroscopic analysis (SEM, BSE and EDS). In another part, the actual adsorption of europium phosphonate onto HA surface was studied. The adsorption was demonstrated based on luminescence studies showing a change of europium environment. In chapter 3, solution behavior of lanthanide complexes of the alpha2-P2W17O 6110- ligand was reported to identify trends that will facilitate rational synthesis of hybrid organic lanthanide polyoxometalate complexes. Based on 31P NMR studies, the equilibrium between the 1:1 and the 1:2 species, that was observed by Pope for the Ce(III) analog is prevalent for the early-mid lanthanides. This equilibrium is slightly dependent on pH but seems to be very much influenced by larger poorly hydrated cations, which appear to favor the 1:2 species for the early to mid lanthanides while they do not appear to influence the equilibrium for the later lanthanides. For all counterions, we found the 1:1 species stable with no trace of the 1:2 species. Finally, in chapter 4, we investigated Eu[alpha1-P 2W17O61]7-- (EuPOM) for a layer by layer deposition application with Zn(phen)32+ (Zn(phen)) and its potential as a electroluminescence device. The depositions were monitored by UV-vis. We successfully fabricated multilayer film via electrostatic interaction between the polyanion EuPOM7- and the polycation Zn(Phen) 32+ until reaching four bilayers when the layers appeared to strip off. Also luminescence studies showed that the multilayer film demonstrated an effective luminescence activity due to the energy transfer through space from the phenanthroline to the europium ion.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Chemistry
