Early sensory processing deficits in schizophrenia
Item
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Title
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Early sensory processing deficits in schizophrenia
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Identifier
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d_2009_2013:9d91484fc593:10401
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identifier
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10327
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Creator
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Leavitt, Victoria M.,
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Contributor
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John J. Foxe
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Date
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2009
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychobiology | Neurosciences | Clinical psychology | auditory | electrophysiology | schizophrenia | sensory processing | visual
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Abstract
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Sensory processing deficits have been found in individuals with schizophrenia across sensory modalities, including auditory, visual, somatosensory, and olfactory systems. These deficits have been identified at very early stages of cortical, and subcortical processing. It remains to be seen whether or not these deficits have implications for higher order cognitive processes and the positive and negative symptoms of schizophrenia. Before we can begin to understand the role they play in the etiology and manifestation of the disease, the deficits themselves must be fully characterized. Three high-density (168-channel) electrophysiological investigations are detailed herein, the first two of which are concerned with the auditory system, and the final, the visual system. First, we present an investigation of the middle latency auditory evoked potentials, a processing period which has not previously been explicated in the schizophrenia literature, and one which represents the transition from brainstem-level processing to late-latency cortical processes. Next, we present a normative investigation of the ventral and dorsal ('what' and 'where') auditory pathways which employed functionally distinct behavioral tasks in an attempt to characterize the evoked componentry within each of the respective pathways. On the basis of the notion that v dorsal and ventral pathways show differential impairment in individuals with schizophrenia, the paradigm was then applied to a group of patients to determine whether the pattern of processing within the two pathways differed from that observed in healthy controls. Finally, we present a visual experiment that employed a monocular deprivation challenge as a means of amplifying known early visual processing deficits in schizophrenia, namely the visual P1 deficit which was recently identified as an endophenotypic marker for schizophrenia. Taken together, the deficits that were identified and characterized within each of these sensory modalities may contribute to an overarching model of sensory processing deficits in schizophrenia wherein the contributions of many decrements, taken together across sensory modalities, result in a profile common to individuals with schizophrenia.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Psychology
