The effects of exogenously administered melatonin (MT) on sleep maintenance insomnia (SMI).
Item
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Title
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The effects of exogenously administered melatonin (MT) on sleep maintenance insomnia (SMI).
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Identifier
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AAI3024778
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identifier
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3024778
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Creator
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D'Ambrosio, Paul.
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Contributor
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Adviser: Arthur J. Spielman
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Date
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2001
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Experimental
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Abstract
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Two studies were conducted to clinically evaluate sleep maintenance insomnia (SMI). The first study was conducted to assess the efficacy of a new therapeutic strategy for SMI. SMI, characterized by poor sleep in the later half of the night, afflicts many mid-life and elderly adults. It has been suggested that this type of insomnia may in part reflect a phase advance in circadian rhythms (Lacks, et al., 1996). The goal of the first study was to assess whether exogenously administered daily physiological doses (0.3 mg.) of MT in the morning would induce an endogenous melatonin onset delay as a treatment for SMI. The study compared the effects of double-blind administration of MT (0.3 mg.) to placebo (PB) ingested in the morning at waketime in two groups of participants experiencing SMI. Outcome measures were: (1) Phase shift in endogenous salivary MT onset time (assessed via salivary DLMO); (2) PSG measures; (3) Subjective assessments of sleepiness; and (4) An insomnia scale.;In the second study, wrist actigraphy (ACT) was recorded simultaneously with polysomnography (PSG) to obtain 51 recordings from 15 subjects. Although overall ACT correlated well with PSG, we examined and scrutinized the reliability of epoch-by-epoch comparison. The main objective of the second study was to assess the accuracy of ACT sleep recording in SMI subjects, identify discordance by epoch-by-epoch comparisons between ACT and PSG, and develop correction factors based on baseline (BL) nights of PSG recordings that can be implemented to subsequent ACT recordings to improve ACT validity.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
