Differential relationships of mismatch negativity and visual P1 deficits to premorbid characteristics and functional outcome in schizophrenia
Item
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Title
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Differential relationships of mismatch negativity and visual P1 deficits to premorbid characteristics and functional outcome in schizophrenia
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Identifier
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d_2009_2013:2c3edb17972b:11608
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identifier
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12180
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Creator
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Friedman, Tamara Shore,
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Contributor
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Daniel Javitt
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Date
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2013
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Language
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English
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Publisher
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City University of New York.
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Subject
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Cognitive psychology | Neurosciences
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Abstract
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Sensory deficits have been consistently observed in patients with schizophrenia, and previous studies have explored relationships between either auditory or visual deficits and various clinical characteristics and patients' global functioning. The present dissertation is the first to assess with EEG both auditory and visual deficits in the same patient sample and to relate each type of deficit to symptoms, present functioning, and premorbid functioning. The first study assessed visual deficits associated with schizophrenia during the concurrent presentation of auditory and visual stimuli. Patients with schizophrenia and healthy controls were presented with both parvocellularly-biased and magnocellularly-biased stimuli while passively listening to an auditory paradigm intended to elicit mismatch negativity responses. By comparing the present visual results to those of a very similar study, which included different visual stimuli, we underscore the importance of utilizing appropriate stimuli in assessing visual deficits in patients with schizophrenia. The purpose of the second study was to assess auditory deficits associated with schizophrenia. Duration, frequency, and intensity deviants were embedded in the auditory mismatch negativity paradigm to which the participants listened during the visual task. Mismatch negativity deficits were assessed, relative to each of the three deviants. We demonstrate that the mismatch negativity results are characteristic of patients with schizophrenia, regardless of the simultaneous visual task in which the participants are engaging. The third study relates the findings of the auditory and visual deficits in patients with schizophrenia to clinical characteristics, including symptoms, present, and premorbid functioning. Differential relationships suggest that different underlying pathophysiological mechanisms may account for impaired visual and auditory neurophysiological dysfunction. This knowledge could help in the treatment and management of schizophrenia.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Psychology
