Fructose-Conditioned Flavor-Flavor Preferences in the Rat: Role of Dopaminergic Receptor Subtypes in the Nucleus Accumbens, Amygdala, and Medial Prefrontal Cortex
Item
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Title
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Fructose-Conditioned Flavor-Flavor Preferences in the Rat: Role of Dopaminergic Receptor Subtypes in the Nucleus Accumbens, Amygdala, and Medial Prefrontal Cortex
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Identifier
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d_2009_2013:43061b59cb9e:11805
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identifier
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12377
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Creator
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Malkusz, Danielle C.,
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Contributor
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Richard J. Bodnar
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Date
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2013
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Language
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English
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Publisher
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City University of New York.
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Subject
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Neurosciences | Behavioral psychology | Physiological psychology | Amygdala | Dopamine | Eating Behavior | Food Preference | Medial Prefrontal Cortex | Nucleus Accumbens
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Abstract
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Systemic administration of dopamine (DA) D1 (SCH23390) and D2 (raclopride) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nucleus accumbens shell (NAC), amygdala (AMY) and medial prefrontal cortex (mPFC) in the acquisition and expression of fructose-CFP. In Experiment 1, separate groups of rats were injected daily in the NAC or AMY with saline, SCH23390 (24 nmol) or raclopride (24 nmol) prior to training sessions with a flavor (CS+) mixed with 8% fructose and 0.2% saccharin (CS+/F) and a different flavor (CS-) mixed with only 0.2% saccharin. In two-bottle choice tests with the CS+ or CS- flavor presented in a 0.2% saccharin solution, only rats injected with raclopride in the AMY failed to acquire a CS+ preference (45-54%). In Experiment 2, new rats were identically trained, but saline, SCH23390 and raclopride were injected in the mPFC. In subsequent two-bottle choice tests, SCH23390---and raclopride---treated rats failed to exhibit a CS+ preference (50-56%). In Experiment 3, new rats were trained with CS+/F and CS-without injections. Subsequent two-bottle choice tests were then conducted following bilateral injections of SCH23390 or raclopride in the mPFC at total doses of 12, 24 and 48 nmol. Expression of the CS+ preference failed to be affected by either antagonist, indicating that the mPFC is not involved in the maintenance of this preference. These data indicate that the acquisition of fructose-CFP is dependent on DA signaling in the mPFC and AMY.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Psychology
