Chemical, biological and analytical studies on natural products from central nervous system-(cns) active plants
Item
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Title
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Chemical, biological and analytical studies on natural products from central nervous system-(cns) active plants
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Identifier
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d_2009_2013:37d4d336c01d:11960
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identifier
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12636
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Creator
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He, Fang,
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Contributor
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Wayne W. Harding
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Date
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2013
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry | Biochemistry | Analytical chemistry
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Abstract
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There are several CNS activities, including analgesic, antidepressant, sedative, euphoric, stimulant, anxiolytic, psychedelic and oneirogenic activity. Investigation of CNS-active plants has the promise to identify new compounds that may be therapeutically useful or that may be useful as probes for CNS receptors. This thesis deals with three plants that have been reported to possess CNS activity: Leonotis leonurus, Silene capensis, and Ipomoea indica. Leonotis leonurus when smoked or consumed as a tea is reported to cause mild marijuana-like sedative effects. Our investigation has uncovered three new labdane diterpenes from an aqueous extract of a commercial source of the plant. The labdane diterpenes tested did not show any CNS receptor affinity at the sites we tested. These compounds are not likely (by themselves) to be responsible for the activity. Silene capensis known as African Dream Root has oneirogenic activity. Phytochemical isolation of our plant material resulted in the isolation of ten known compounds. Six of these ten compounds are withanolides or withanolide glycosides. No phytochemical investigations of Ipomoea indica have been reported to date. Eight known compounds were isolated during our investigation.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Chemistry
