The influence of hepatocyte growth factor during phagocytosis by retinal pigment epithelium
Item
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Title
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The influence of hepatocyte growth factor during phagocytosis by retinal pigment epithelium
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Identifier
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d_2009_2013:84dd133fa05c:11976
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identifier
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12647
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Creator
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Blaize, Jonathan Franklin,
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Contributor
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William J. L'Amoreaux
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Date
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2013
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology | Neurosciences | HGF | Phagocytosis | RPE
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Abstract
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Processing of photoreceptor outer segments (OS) by the RPE is critical for maintaining the health of the neural retina. If any portion of OS processing is disrupted, or if the RPE suffer injury, subsequent inhibition of OS processing has deleterious effects. Therefore, it is crucial to understand OS processing in order to maintain visual health.1 Sub-retinal clearance of OS by RPE is facilitated by phagocytosis featuring both RPE-specific and Fc gamma receptor associated signaling cascades.2 Integration of these two pathways renders RPE capable of internalizing both specific and non-specific targets. To accomplish these tasks, there must be specific pathways available to present the cell with the protein machinery necessary for binding, internalizing and processing OS. The discovery that lack of c-Met signaling results in impaired phagocytosis in alveolar and hepatocyte macrophages suggests c-Met's role as modulator of phagocytosis.3 These data also suggest a role for hepatocyte growth factor (HGF), the natural ligand for c-Met activation, in preparing phagocytes for clearance of cellular debris. We propose that HGF activation of c-Met in RPE prepares these cells for phagocytosis by initiating a signaling cascade that includes activation of phosphatidylinositol-3 kinase (PI3K). Subsequent activation of Rac1 by PI3K may regulate phagosome formation.4,5.
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Type
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dissertation
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Source
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2009_2013.csv
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degree
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Ph.D.
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Program
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Biology
