Mimetics of beta-galactosylceramide with simple ceramide substitutes: Synthesis and binding to gp 120 of HIV -1, and, Enactment of chemistry knowledge by a high school student at a summer program.
Item
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Title
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Mimetics of beta-galactosylceramide with simple ceramide substitutes: Synthesis and binding to gp 120 of HIV -1, and, Enactment of chemistry knowledge by a high school student at a summer program.
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Identifier
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AAI3232037
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identifier
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3232037
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Creator
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Augustin, Line A.
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Contributor
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Advisers: David R. Mootoo | Pamela Mills
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Date
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2006
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Organic | Education, Sciences
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Abstract
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This thesis is the account of two research works. The first part reports the synthesis of O- and C- and aza-C-glycosides of beta-Galactosylceramide (GalCer) that contain simple ceramide substitutes, and the initial results of their binding with gp120 of HIV-1. The O-glycosides were prepared via an established procedure. The C- and aza-C-glycosides originated from a central C1-substituted galactal precursor, and their synthesis is illustrative of a potentially general method for pairs of C- and aza-C-beta-galactosides. They aza-C-glycoside with a simple C-17 hydrocarbon chain exhibited significant higher affinity than GalCer, whereas the corresponding C-glycoside was as active as GalCer.;The second part describes the ethnographic study of the enactment of the chemistry knowledge of a high school student at a summer program and the influence of a cultural practice, othermothering, on her ability to perform well on her chemistry Regents Exams. Kelly, an 11th grade student exhibited very good understanding of the chemistry curriculum in the classroom, the laboratory period and the tutoring sessions where she plays a caring role for her peers. The same level of understanding was not reflected on the paper pencil exams taken during the summer program.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
