A role for phospholipase D in cell cycle control and transformation.

Title: A role for phospholipase D in cell cycle control and transformation.
Identifier: AAI3037407
identifier: 3037407
Creator: Joseph, Troy William.
Contributor: Adviser: David A. Foster
Date: 2002
Language: English
Publisher: City University of New York.
Subject: Chemistry, Biochemistry | Biology, Cell
Abstract: Phospholipase D (PLD) activity is elevated in response to most mitogenic signals. Two mammalian PLD genes (PLD1 and PLD2) have been cloned and their gene products characterized. PLD1 is a downstream target of the Ras/RaIA GTPase cascade implicated in mitogenic and oncogenic signaling. Consistent with a role in mitogenic signaling, elevated expression either of PLD1 or PLD2 results in the transformation of cells overexpressing either c-Src or the epidermal growth factor (EGF) receptor (EGFR). Both PLD1 and PLD2 were also able to overcome cell cycle arrest induced by high intensity Raf signaling.;These data suggest that elevated PLD activity may be an important factor in progression to a malignant phenotype in cells with elevated tyrosine kinase activity. The overexpression of a tyrosine kinase is a common genetic alteration in several human cancers. Also, PLD activity provides a novel survival signal(s) that overcomes the inhibitory effects of high intensity Raf signaling on cell cycle progression.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.