The effect of mutant superoxide dismutase 1 (SOD1) on cognitive behavior in the transgenic model of amyotrophic lateral sclerosis (ALS).
Item
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Title
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The effect of mutant superoxide dismutase 1 (SOD1) on cognitive behavior in the transgenic model of amyotrophic lateral sclerosis (ALS).
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Identifier
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AAI3037427
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identifier
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3037427
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Creator
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Murphy, Peregrine L.
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Contributor
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Adviser: Victoria N. Luine
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Date
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2002
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Psychobiology | Psychology, Behavioral | Psychology, Cognitive
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Abstract
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The primary goal of this study was to determine if mutations in Superoxide dismutase 1 (SOD1) affected cognition before first physical symptom onset in the transgenic (Tg) animal model of familial amyotrophic lateral sclerosis (FALS). A secondary aim of the study was to identify how neurochemical activity was affected in brain regions known for cognition and memory function. The Tg line of mice carrying the mutant gene for SOD1 (MSOD1 Tg+) and the Tg line of mice over-expressing normal human SOD1 (WT SOD1 Tg+) and both lines non-transgenic littermates (Tg-) were evaluated with the Eight-Arm Radial Maze (RAM), a frontal cortex and hippocampal dependent memory task. Results showed: (1) younger MSOD1 mice performed better than older MSOD1 mice; and (2) Tg+ mice carrying the SOD1 gene, whether mutated or over-expressed, recorded more errors on the RAM when compared with Tg- littermates. Amino acids and monoamines were significantly different between the two lines of mice and differences were influenced by the presence of the transgene, gender, and the age of the mice when euthanized.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
