THEORY OF ANTIGEN-ANTIBODY INDUCED PARTICULATE AGGREGATION.
Item
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Title
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THEORY OF ANTIGEN-ANTIBODY INDUCED PARTICULATE AGGREGATION.
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Identifier
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AAI8023664
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identifier
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8023664
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Creator
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CHAK, KI-CHUEN.
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Contributor
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Hiram Hart
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Date
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1980
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Language
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English
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Publisher
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City University of New York.
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Subject
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Physics, General
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Abstract
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Theoretical approaches on particulate aggregation phenomena are reviewed. The validity and incompleteness of these existing theories when applied to antigen-antibody agglutinating systems are studied.;A theory of antigen-antibody induced particulate aggregation is developed by investigating the stability of model systems of particles. Conditions for the formation of large aggregates are derived by imposing the requirement that at equilibrium a statistically significant number of redundant bonds would occur in a reduced monomer-dimer model system. A relationship is obtained which predicts the fractional agglutination in the reduced dimer system as a function of the antigen, antibody and particulate concentrations as well as the physical chemical factors of association, dissociation and geometric orientations.;The roles of all the relevant factors in the aggregation are analysed in detail. It is shown that the basic relationship derived from the dimer model is consistent over a broad range of conditions with experimental findings previously reported.;The dimer theory has been extended to provide for the two extreme cases of either pure linear chain formation or pure spherical growth. In both cases, a sufficient condition for complete aggregation can be obtained analytically from the critical value at which an infinite series diverges. Theoretical comparisons between the extended models and other theories on antigen-antibody aggregation systems are also carried out. The predicted results are in good agreements.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Physics
