CO-EVOLUTION OF AGING, REJUVENATION, AND SEXUALITY DURING THE EVOLUTION OF EUKARYOTIC CELLS: A POSSIBILITY SUGGESTED BY SIMILARITIES BETWEEN BACTERIAL CONJUGATION AND EUKARYOTE MEIOSIS, AND EVIDENCE OF DNA REPAIR DURING EACH.

Title: CO-EVOLUTION OF AGING, REJUVENATION, AND SEXUALITY DURING THE EVOLUTION OF EUKARYOTIC CELLS: A POSSIBILITY SUGGESTED BY SIMILARITIES BETWEEN BACTERIAL CONJUGATION AND EUKARYOTE MEIOSIS, AND EVIDENCE OF DNA REPAIR DURING EACH.
Identifier: AAI8123027
identifier: 8123027
Creator: MARTIN, ROLF JOHN.
Contributor: Aaron Lukton | Stanley N. Salthe
Date: 1981
Language: English
Publisher: City University of New York.
Subject: Chemistry, Biochemistry
Abstract: Computer simulations and theoretical models describing aging, rejuvenation during sexual activity, and the evolution of each are presented and discussed. Aging is attributed to an inevitable ontogenetic selection for stable molecular aggregates. Alterations in DNA and chromatin, particularly in "hotspots" of damage which result in gene dosage imbalance, are suggested to be of prime importance. Rejuvenation during sexual activity is proposed to occur, in part, when homologous chromosomes pair with each other and exchange repair templates which enable much of the accumulated damage to be removed. This system of repair is suggested to have originated from DNA repair during bacterial conjugation as a result of evolutionary selection for radiation and mutagen resistance, energy efficiency during repair, and genetic recombination.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.
Program: Biochemistry

Media: CO-EVOLUTION OF AGING, REJUVENATION, AND SEXUALITY DURING THE EVOLUTION OF EUKARYOTIC CELLS: A POSSIBILITY SUGGESTED BY SIMILARITIES BETWEEN BACTERIAL CONJUGATION AND EUKARYOTE MEIOSIS, AND EVIDENCE OF DNA REPAIR DURING EACH.