THYMUS GLAND, VITAMIN D AND SEASONAL INFLUENCES ON ELECTROLYTE METABOLISM.
Item
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Title
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THYMUS GLAND, VITAMIN D AND SEASONAL INFLUENCES ON ELECTROLYTE METABOLISM.
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Identifier
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AAI8203274
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identifier
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8203274
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Creator
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DESROCHES, DANIELLE.
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Contributor
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Prof. Constance R. Martin
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Date
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1981
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, Animal Physiology
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Abstract
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Male hooded rats were thymectomized (TMX), sham-thymectomized (SHAM), parathyroidectomized-thymectomized (PX-TMX), parathyroidectomized-sham thymectomized (PX-SHAM), thyroparathyroidectomized-thymectomized (TPX-TMX) or thyroparathyroidectomized-sham thymectomized (TPX-SHAM) at 7-8 weeks and maintained in individual metabolism cages. They were given tap water and either Purina Chow (regular diet) and/or vitamin D-deficient diet for control and injection periods of 3 weeks each. Urinary electrolytes were measured weekly and the values were corrected for food intakes. Serum calcium (Ca) and inorganic phosphate (P) were measured prior to and following vitamin D treatment.;All surgical groups on the regular diet excreted more chloride (Cl) but less inorganic phosphate, sodium, potassium and calcium during April-August than during November-March TMX, PX-TMX and TPX-TMX animals excreted more chloride calcium, sodium and phosphate than SHAM, PX-SHAM and TPX-SHAM groups respectively during July-August, but thymectomy had little effect during the winter months. Parathyroidectomized rats (PX-SHAM, PX-TMX, TPX-SHAM, TPX-TMX) excreted more chloride, potassium and calcium than TMX and SHAM in July-August. SHAM animals had the highest serum Ca and P concentrations in both summer and winter. Parathyroidectomy and thyroparathyroidectomy reduced Ca and elevated serum P levels more markedly in the summer. TMX and PX-TMX rats had lower serum Ca concentrations than SHAM and PX-SHAM animals respectively in both winter and summer. 400 IU vitamin D(,3) (D(,3)) 3x weekly in April-August increased Cl excretion in SHAM only, but it decreased Ca excretion in PX-SHAM, TPX-SHAM, PX-TMX and TPX-TMX rats. This dose also elevated serum Ca levels of all groups. 4,000 IU D(,3) 3x weekly tremendously increased Ca, P and Cl excretion and serum Ca levels in all PX groups. During November-March, 400 IU D(,3) 3x weekly increased Cl and Ca excretion in SHAM, PX-SHAM and TPX-SHAM but not thymectomized rats, while 800 IU D(,3) increased Cl but decreased Ca excretion in TMX and SHAM rats.;TMX and SHAM rats, when fed a D-deficient diet during April-August, excreted more P, but less Cl, K than when fed the regular diet. The serum concentrations of Ca and P were not greatly affected by the deficient diet. 800 IU D(,3) 3x weekly to D-deficient TMX and SHAM elevated serum Ca and Cl excretion values but lowered Ca, P, Na and K excretion.;These findings show influences of the thymus gland on electrolyte metabolism, on seasonal variations in responses to vitamin D administration and on responses to surgical manipulations of the endocrine system that affect Cl, Na, K as well as Ca and P metabolism.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Biology
