THE PARAVENTRICULAR HYPOTHALAMUS AND FEEDING BEHAVIOR.
Item
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Title
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THE PARAVENTRICULAR HYPOTHALAMUS AND FEEDING BEHAVIOR.
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Identifier
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AAI8312332
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identifier
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8312332
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Creator
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ARAVICH, PAUL F.
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Contributor
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Anthony Sclafani | Israel Abramov
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Date
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1983
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Psychobiology
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Abstract
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The role of the paraventricular hypothalamus (PVH) in the feeding behavior of the rat was explored in several experiments. Experiment 1 compared the PVH hyperphagia syndrome to the classic hypothalamic hyperphagia syndrome. PVH lesions and medial hypothalamic (MH) knife cuts produced hyperphagia and overweight on a chow diet although the PVH effect was smaller than the knife-cut effect. Each treatment also produced qualitatively similar ingestive responses to two unpalatable and two palatable diets during the dynamic and static weight-gain phases. The PVH lesions and MH cuts disrupted day/night feeding patterns and elevated water intakes but did not alter water/food intake ratios. PVH lesions, unlike MH cuts, did not increase emotional reactivity. It was concluded that the system responsible for hypothalamic hyperphagia is importantly but not exclusively associated with PVH.;The relationship between the fiber systems mediating the hypothalamic hyperphagia syndrome and the ingestive effects following norepinephrine (NE) stimulation of the PVH was explored in Experiments 2-4. Various types of hypothalamic knife cuts in a position to sever the pathway implicated in hypothalamic hyperphagia failed to alter the NE-feeding effect. It was concluded that the output of the NE-feeding system is independent of the system responsible for hypothalamic hyperphagia.;Experiments 5-7 determined if the PVH NE-feeding system mediates the ingestive response to glucoprivation induced by 2-deoxy-D-glucose (2DG). It was found that, in contrast to systemic 2DG injections, injections of alpha-adrenergic agonists (NE and clonidine) into the PVH did not produce a preference for a 20% sucrose diet over a 20% fat diet. It was also shown that injections of the alpha-adrenergic antagonist phentolamine into the PVH or the dorsomedial hypothalamus blocked feeding induced by moderate food deprivation as well as 2DG-elicited feeding. Phentolamine injections into these sites failed to block the sucrose-diet preference effect elicited by 2DG. Finally, it was found that PVH lesions do not impair 2DG feeding. It was concluded that the PVH NE-feeding system is independent of the glucoprivic-feeding system.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
