INTERACTION BETWEEN THE BENZODIAZEPINE SYSTEM AND PITUITARY-ADRENAL AXIS.
Item
-
Title
-
INTERACTION BETWEEN THE BENZODIAZEPINE SYSTEM AND PITUITARY-ADRENAL AXIS.
-
Identifier
-
AAI8319772
-
identifier
-
8319772
-
Creator
-
JACKSON, DORIS MARGARET.
-
Contributor
-
Prof. Robert L. Thompson
-
Date
-
1983
-
Language
-
English
-
Publisher
-
City University of New York.
-
Subject
-
Psychology, Psychobiology
-
Abstract
-
In a biochemical and behavioral study, interaction between the benzodiazepine system and the pituitary-adrenal axis was investigated. Blood-borne substances of 16,000 daltons and 2,000 daltons with brain benzodiazepine binding inhibitory capacity were characterized as heat and acid labile, hydrophilic, and putatively proteinaceous in nature. The 2,000 dalton moiety may represent a fragment of the 16,000 dalton substance. Inhibitory capacity of these serum components was also present in hypophysectomized and adrenalectomized rats. Benzodiazepine receptor densities in the hippocampus, cortex, and cerebellum were unaltered by hypophysectomy and adrenalectomy. It was concluded that neither the pituitary nor the adrenal gland mediate benzodiazepine activity through regulating levels of the putative endogenous ligand or receptor densities in these brain areas.;The benzodiazepine-sensitive, thirsty-rat punishment conflict model of anxiety was used to examine the effects of shock intensity and chlordiazepoxide; and then at a constant shock intensity of 0.2 milliamperes, the effects of ACTH(,4-10), corticosterone, adrenalectomy, and hypophysectomy. Adrenalectomized and hypophysectomized rats were run with and without acute chlordiazepoxide treatment. ACTH(,4-10) effects were also examined against a background of chronic chlordiazepoxide treatment. No significant effect for any hormone or surgical treatment was found except for an anxiolytic effect of ACTH(,4-10) in animals pretreated for five consecutive days with i.p. injections of water. It was tentatively concluded that ACTH(,4-10) which is usually anxiogenic may have an anxiolytic effect in animals sensitized by some pretreatments.
-
Type
-
dissertation
-
Source
-
PQT Legacy CUNY.xlsx
-
degree
-
Ph.D.
-
Program
-
Psychology
