CENTRAL NEURAL MECHANISMS MEDIATING FEEDING AND ANOREXIA INDUCED BY MONOAMINERGIC DRUGS.
Item
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Title
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CENTRAL NEURAL MECHANISMS MEDIATING FEEDING AND ANOREXIA INDUCED BY MONOAMINERGIC DRUGS.
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Identifier
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AAI8401945
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identifier
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8401945
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Creator
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MCCABE, JOSEPH THOMAS.
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Contributor
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Thomas E. Frumkes
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Date
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1983
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Physiological
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Abstract
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Studies which report central injections of norepinephrine and clonidine stimulate feeding, and administration of dopamine, amphetamine, and fenfluramine suppress feeding suggest these drugs may be acting via the hypothalamus. The present series of experiments has attempted to determine hypothalamic regions where these drug effects are mediated, and has attempted to delineate the course of neural fiber systems that mediate these drug effects. Norepinephrine, clonidine, amphetamine, dopamine, and fenfluramine were administered to selected groups of rats that had sustained electrolytic lesions in the hypothalamus, or coronal wire knife cuts (KCs) either at the level of the posterior hypothalamus, midbrain, or pons.;Electrolytic lesions of the paraventricular nucleus attenuated feeding induced by intraperitoneal administration of clonidine. Lesions of the perifornical region abolished anorexia induced by amphetamine. Caudal, midlateral hypothalamic KCs attenuated anorexia induced by central and peripheral administration of amphetamine. Coronal KCs at the midbrain level that severed tissue dorsal to the medial lemniscus attenuated anorexia induced by central and peripheral injections of amphetamine. Dorsal pontine KCs, rostral or caudal to the level of the locus coeruleus, attenuated feeding elicited by paraventricular injections of norepinephrine and intraperitoneal injections of clonidine. Ventral pontine cuts, dorsal to the nucleus of the facial nerve, significantly decreased anorectic response to amphetamine.;It is suggested that an efferent fiber system(s) originating in the paraventricular nucleus mediates feeding induced by norepinephrine and clonidine. These paraventricular nucleus fibers that mediate norepinephrine and clonidine eating project caudally from the paraventricular nucleus through the periventricular region. At the level of the rostral pons, fibers move lateral and then farther caudal to perhaps the dorsal vagal complex. Amphetamine-induced anorexia was disrupted by presumably severing afferents to the perifornical region that mediate drug response by releasing endogenous catecholamines. Catecholamine fibers that mediate amphetamine-induced anorexia arise from medullary cell groups and ascend through the ventral half of the pons. At the midbrain level, these fibers are joined by midbrain dopamine fibers and these continue rostrad through the midbrain and hypothalamus and terminate in the perifornical region.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
