PART I. SUPERCRITICAL FLUID EXTRACTION OF ORGANICS FROM URBAN AEROSOL. PART II. N-NITROSOMOPHOLINE AND OTHER VOLATILE N-NITROSAMINES IN SNUFF TOBACCO. PART III. N-NITROSOPROLINE, AN INDICATOR FOR N-NITROSATION OF AMINES IN PROCESSED TOBACCO.
Item
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Title
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PART I. SUPERCRITICAL FLUID EXTRACTION OF ORGANICS FROM URBAN AEROSOL. PART II. N-NITROSOMOPHOLINE AND OTHER VOLATILE N-NITROSAMINES IN SNUFF TOBACCO. PART III. N-NITROSOPROLINE, AN INDICATOR FOR N-NITROSATION OF AMINES IN PROCESSED TOBACCO.
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Identifier
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AAI8409417
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identifier
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8409417
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Creator
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SCOTT, JOHN CHARLES.
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Contributor
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David C. Locke
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Date
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1984
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical
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Abstract
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Part I. This study examines whether supercritical carbon dioxide can be used for the extraction of polycyclic aromatic hydrocarbons from high volume air pollution filters. Current analytical methods begin with a six to eight hour soxhlet extraction of the filter, followed by a reduction of the solvent by evaporation. Using supercritical carbon dioxide, it has been shown that one can perform an extraction in less than thirty minutes and obtain comparable results as in soxhlet extractions using cyclohexane. The percent recoveries of compounds ranging from fluorene to indeno(1,2,3-c,d)pyrene are 96.7% and 89.4% respectively. In addition to extractions, the solubilities of various organics at varying temperatures and pressures were determined. The enhancement in solubility over the expected vapor pressure ranged from 1.00 x 10('3) for fluoranthene (55(DEGREES)C, 136 atm.) to 4.91 x 10('8) for benz(a)anthracene (37(DEGREES)C, 408 atm.). This study has shown that supercritical carbon dioxide can be used to extract organics from air pollution filters.;Part II. Seven out of ten popular snuff brands from the U.S.A. and Sweden that were analyzed for N-nitrosamines contained N-nitrosomorpholine (NMOR), a strong animal carcinogen. A model study with the container waxes indicate that NMOR can possibly be formed by way of diffusion of the morpholine into the snuff and subsequent N-nitrosation.;Part III. Free proline is found in green leaves up to 2,000 ppm and in processed tobacco up to 4,000 ppm. Since it is amenable to N-nitrosation, it was examined whether N-nitrosoproline (NPRO) can serve as a reliable indicator of the extent to which amines can be N-nitrosated during processing and smoking of tobacco. Correlations of NPRO and NNN (r('2) = 0.961) or TSNA (r('2) = 0.899) support the concept that NPRO can serve as an indicator of N-nitrosation.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Chemistry
