ELECTROPHYSIOLOGIC CONSEQUENCES OF BLOOD-BRAIN BARRIER DISRUPTION (EEG).
Item
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Title
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ELECTROPHYSIOLOGIC CONSEQUENCES OF BLOOD-BRAIN BARRIER DISRUPTION (EEG).
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Identifier
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AAI8501191
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identifier
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8501191
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Creator
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ZAPPULLA, ROSARIO ANTHONY.
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Contributor
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Jeffrey J. Rosen
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Date
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1984
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Physiological
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Abstract
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This study investigates the acute (up to three hours) and chronic (up to 72 hours) electrophysiologic consequences in rats of blood-brain barrier (BBB) disruption by the intracarotid infusion of the bile salt sodium dehydrocholate. The epileptogenic properties of dehydrocholate and its possible role in barrier disruption were also examined.;Experiment I documents the electroencephalographic (EEG) and visual evoked potential (VEP) changes associated with various grades of disruption. These electrophysiologic changes tended to be the most severe and persist the longest in those animals with the most extensive disruption.;Experiment II was a replication of Experiment I with the addition of pre-testing the animals with diazepam, an anti-epileptic. While the intensity of the seizure activity was markedly reduced as compared to animals in Experiment I, there was no change in the distribution of the various grades of disruption and their associated EEG and VEP alterations.;The EEG was monitored in Experiment III following BBB disruption and compared to pre-disruption EEG in two groups of animals using visual inspection of the EEG (24 hours following disruption) as well as quantitative spectral analysis (24, 48, 72 hours following disruption). Minor reversible changes in EEG occurred in these chronic animals.;The final two experiments detailed the epileptogenic properties of dehydrochlolate. Experiment IV demonstrated the epileptogenic effects of dehydrocholate independent of its effects on the BBB. Experiment V investigated the development, configuration and propagation of spike activity following the local application of dehydrocholate to the cortical surface.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
