SYNTHESIS OF POTENTIAL ORGANOPHOSPHORUS METABOLIC REGULATORS (I-CYCLOALKENYL PHOSPHONATES OLIGOPEPTIDES, PHOSPHONIC ACID).
Item
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Title
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SYNTHESIS OF POTENTIAL ORGANOPHOSPHORUS METABOLIC REGULATORS (I-CYCLOALKENYL PHOSPHONATES OLIGOPEPTIDES, PHOSPHONIC ACID).
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Identifier
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AAI8508686
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identifier
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8508686
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Creator
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BANERJEE, SHYAMAL C.
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Contributor
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Robert Engel
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Date
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1985
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Organic
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Abstract
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The present thesis program has been concerned with two related areas of organophosphorus chemistry. These involve new methods of generating carbon-phosphorus bonds and the application of organophosphorus chemistry to metabolic regulation. Specifically, a method for the generation of vinylic carbon-phosphorus bonds has been applied to the synthesis of cylic vinyl phosphonates, and a series of potential organophosphorus antimetabolites conjugated with chemical vectors has been synthesized.;The purpose of the oligopeptide is to enable transport of the potential organophosphorus agents into intact cells. Several phosphonic acids have been used, including 4-hydroxy-3-oxobutyl-1-phosphonic acid, 3,4-dihydroxybutyl-1-phosphonic acid, and 5-carboxy-4-hydroxy-4-methylpentyl-1-phosphonic acid.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Chemistry
