PAIN SENSITIVITY, MOOD, AND PLASMA ENDOCRINE LEVELS IN MAN FOLLOWING LONG-DISTANCE RUNNING: EFFECTS OF NALOXONE (STRESS-INDUCED ANALGESIA, OPIOID PEPTIDES).
Item
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Title
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PAIN SENSITIVITY, MOOD, AND PLASMA ENDOCRINE LEVELS IN MAN FOLLOWING LONG-DISTANCE RUNNING: EFFECTS OF NALOXONE (STRESS-INDUCED ANALGESIA, OPIOID PEPTIDES).
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Identifier
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AAI8508705
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identifier
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8508705
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Creator
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JANAL, MALVIN NEIL.
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Contributor
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W. Crawford Clark
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Date
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1985
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Psychobiology
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Abstract
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Anecdotal observations and research reports have suggested an association between stressful environmental situations (e.g., war, auto accidents, or athletic competition) and reduced sensitivity to painful stimuli. Further, exercise stress in particular has been associated with mood elevation, popularly known as runner's high. These two phenomena, analgesia and euphoria, are major effects of opiate drugs. Recent demonstrations of endogenous opiate-like peptides and receptor sites in the central nervous system of all vertebrates suggest that stress may have its effect on pain sensitivity and mood through alterations of activity at the opiate receptor. To examine these relationships, the effects of intense exercise on pain perception, mood, and plasma endocrine levels in man were studied under naloxone and saline conditions.;Twelve long-distance runners (mean weekly mileage = 41.5) were evaluated on thermal, ischemic and cold pressor pain tests and on mood visual analogue scales (VAS). Blood was drawn for determination of plasma levels of beta-endorphin immunoreactivity (BEir), growth hormone (GH), adrenocorticotrophic hormone (ACTH), and prolactin (PRL). These procedures were undertaken before and after a 6.3 mile run at 85% of maximal aerobic capacity.;Sensory decision theory analysis of the responses to thermal stimulation and visual analogue scale ratings show that long-distance running produces hypoalgesia and mood elevation in man.;Plasma levels of BEir, ACTH, GH, and PRL were significantly increased post-run. Correlational analysis of changes in pain sensitivity and plasma hormone levels indicate an association of analgesia and hyposecretion of ACTH and hypersecretion of PRL, effects consistent with a common underlying opioid mechanism. These effects were evident only at test periods within 30 min of completion of the run, consistent with the half-life of beta-endorphin, suggesting that activity of the peptide may underlie the covariation of analgesia and changes in ACTH and PRL levels. Analysis of correlations between hormone levels and mood reports did not consistently suggest opioid mediation of effects.;The effects of naloxone and correlations between behavioral changes and pituitary hormone levels implicate endogenous opioid neural systems as mechanisms of some but not all the run-induced alterations in mood and pain perception. (Abstract shortened with permission of author.).
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
