dizzy, a novel gene required for axon guidance in the visual system of Drosophila.

Title: dizzy, a novel gene required for axon guidance in the visual system of Drosophila.
Identifier: AAI3083644
identifier: 3083644
Creator: Bottalico, Anthony Gianvito.
Contributor: Adviser: Qi He
Date: 2003
Language: English
Publisher: City University of New York.
Subject: Biology, Neuroscience | Biology, Molecular | Biology, Cell
Abstract: Retinal axons in the Drosophila visual system traverse long distance and make several critical projection decisions en route. Elucidating genes required for retinal axon pathfinding is thus essential for understanding mechanisms governing the development of the CNS. Identified in our screening for genes required for the visual system development, dizzy encodes a protein regulating the pathfinding of the retinal axons. In dizzy mutants, retinal axons make abnormal projections to their targets in the lamina while the photoreceptors appear normal. The full cDNA sequence for dizzy has been obtained and it encodes a novel guanine nucleotide exchange factor of 1573 amino acids with a Ras/Rap1A-associating domain. The combined molecular, cellular and genetic analyses demonstrate that Dizzy is a critical mediator of axon pathfinding with a possible regulatory role in the growth cone cytoskeleton reorganization.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.

Media: dizzy, a novel gene required for axon guidance in the visual system of Drosophila.