HEMODYNAMIC RESPONSE PATTERNING TO COGNITIVE AND COLD STRESSORS: MECHANISMS AND MODIFICATION WITH DIAZEPAM.
Item
-
Title
-
HEMODYNAMIC RESPONSE PATTERNING TO COGNITIVE AND COLD STRESSORS: MECHANISMS AND MODIFICATION WITH DIAZEPAM.
-
Identifier
-
AAI8515673
-
identifier
-
8515673
-
Creator
-
WILSON, BRUCE L.
-
Contributor
-
Solomon S. Steiner
-
Date
-
1985
-
Language
-
English
-
Publisher
-
City University of New York.
-
Subject
-
Psychology, Physiological | Health Sciences, Pharmacology
-
Abstract
-
This series of studies is based upon the premise that the behavioral topography of the heart cannot be adequately described with the traditional psychophysiological variables of heart rate and blood pressure. The technique of impedance cardiography was used to allow the examination of additional dimensions of cardiovascular behavior. These additional variables include: stroke volume, cardiac output, myocardial contractility, and total peripheral resistance. The first experiment was designed to replicate the findings of a pilot study which examined borderline hypertensive subjects using a within subjects design. The pilot data revealed that cognitive tasks and the cold pressor test produce similar changes in blood pressure through very different patterns of underlying hemodynamic activity. Twenty-four additional subjects were added to the analysis. The existence of differential hemodynamic patterning to these two stress conditions was confirmed. Analyses of variance for all variables were significant at or beyond the .01 level.;The second study investigated the role of increased peripheral resistance in the production of decreased stroke volume, cardiac output, and cardiac contractility during the cold pressor tests. The cognitive stress condition and a new physical stressor - sustained isometric contraction were administered to nine normotensive subjects. Isometric contraction was found to produce hemodynamic patterning similar to that elicited by cold stress. All variables were significant at the .05 level. When the procedure was repeated with the same subjects, the stimulus specific patterns were found to be preserved.;In the third study fourteen normotensive subjects were randomly assigned to receive an anxiolytic compound, diazepam, or an active placebo. The drugs were administered in a single blind fashion prior to the administration of a second stress test procedure. The variables produced by impedance cardiography were able to discriminate the differential effects of the drug at or beyond the .02 level of significance. These findings support the use of a systems approach in the study of central nervous system control of cardiovascular behavior and demonstrate the utility of adopting new hemodynamic variables in behavioral research.
-
Type
-
dissertation
-
Source
-
PQT Legacy CUNY.xlsx
-
degree
-
Ph.D.
-
Program
-
Psychology
