STUDIES DIRECTED TOWARDS TOTAL SYNTHESIS OF TAXANE ALKALOIDS. (I) AN APPROACH TO THE D-RING OF TAXOL. (II) AN INTRAMOLECULAR PHOTOCYCLOADDITION APPROACH TO THE TAXANE SKELETON (BACCATIN III, OXETANE, CYCLOCTANE).
Item
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Title
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STUDIES DIRECTED TOWARDS TOTAL SYNTHESIS OF TAXANE ALKALOIDS. (I) AN APPROACH TO THE D-RING OF TAXOL. (II) AN INTRAMOLECULAR PHOTOCYCLOADDITION APPROACH TO THE TAXANE SKELETON (BACCATIN III, OXETANE, CYCLOCTANE).
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Identifier
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AAI8601620
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identifier
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8601620
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Creator
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AMARASEKARA, ANANDA SARATH.
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Contributor
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William F. Berkowitz
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Date
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1985
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Organic
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Abstract
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Taxol 1a, Cephalomannine 1b and Baccatin III 1c are polyoxy- genated diterpenoids isolated from Taxus species.;(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI).;Two key aspects in the synthesis of these compounds have been investigated. In the first phase a method was developed which is.;applicable to the construction of the Oxetane (D ring)/tertiary acetate grouping of Taxol (Baccatin III, Cephalomannine).;(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI).;In the second phase model studies have been carried out in.;development of an intramolecular photocycloaddition approach applicable in the construction of the Taxane skelton.;(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI).
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Chemistry
