AN ANALYSIS OF THE MECHANISMS UNDERLYING SEPTAL AREA AND CINGULATE GYRUS CONTROL OF HYPOTHALAMICALLY ELICITED AGGRESSION IN THE CAT (LIMBIC SYSTEM, ELECTRICAL STIMULATION, AGGRESSION, 2-DEOXYGLUCOSE).
Item
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Title
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AN ANALYSIS OF THE MECHANISMS UNDERLYING SEPTAL AREA AND CINGULATE GYRUS CONTROL OF HYPOTHALAMICALLY ELICITED AGGRESSION IN THE CAT (LIMBIC SYSTEM, ELECTRICAL STIMULATION, AGGRESSION, 2-DEOXYGLUCOSE).
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Identifier
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AAI8611332
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identifier
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8611332
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Creator
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BRUTUS, MARTIN.
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Contributor
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Solomon S. Steiner
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Date
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1986
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Physiological
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Abstract
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This experiment was performed in order to examine several of the underlying mechanisms by which the septal area and adjacent regions regulate quiet biting attack behavior elicited from electrical stimulation of the hypothalamus in the cat. This behavior begins with quiet stalking of the rat and ends with a lethal bite directed at the back of a rat's neck. There is little sympathetic nervous system involvement other than some pupillary dilation.;The results indicate that stimulation of the septal area and anterior cingulate gyrus increased the latency for the occurrence of quiet biting attack behavior. Those sites within the septal area from which inhibition of attack can be produced are linked to sensory mechanisms associated with trigeminal reflexes activated during hypothalamic stimulation. Stimulation of these septal area sites decreased the lateral extent of the "effective" sensory fields of the lipline established during hypothalamic stimulation, but did not appear to have any effect upon the latency of the hypothalamically-elicited jaw opening response.;('14)C -2-deoxy-D-glucose is a labeled structural analogue of glucose which can serve as a marker for increased glucose utilization. Since it has been established that a close relationship exists between energy metabolism and functional activity in central nervous system tissues, it has been possible to provide pictorial representations of the relative rates of glucose utilization during different stimulation elicited behaviors. Deoxyglucose autoradiography revealed that the inhibition resulting from stimulation of the lateral septal area may be due to either the monosynaptic activation of the lateral hypothalamus or the polysynaptic activation of this area utilizing a circuit involving the nuclei of the diagonal band of Broca.;It would appear that such limbic system structures as the septal region and cingulate gyrus provide tonic and/or phasic inhibitory control over hypothalamic organization of aggressive behavior, thereby reducing aggressive behavior to levels appropriate to the organism's stimulus environment. They do this in part, by modulating the trigeminal sensory components of the attack response. A fuller understanding of the neuropathology, neuropharmacology and neuroanatomy of aggression can allow for noninvasive drug or other therapeutic strategies to control nonadaptive aggressive behavior.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
