NIGRO-STRIATAL ASYMMETRY AND ROTATIONAL BEHAVIOR IN RATS: NEUROCHEMICAL, ANATOMICAL, AND FUNCTIONAL EVIDENCE FOR A TWO POPULATION MODEL (AMPHETOMINE, DOMINANCE, LATERALIZATION, DOPAMINE).
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Title
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NIGRO-STRIATAL ASYMMETRY AND ROTATIONAL BEHAVIOR IN RATS: NEUROCHEMICAL, ANATOMICAL, AND FUNCTIONAL EVIDENCE FOR A TWO POPULATION MODEL (AMPHETOMINE, DOMINANCE, LATERALIZATION, DOPAMINE).
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Identifier
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AAI8611382
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identifier
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8611382
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Creator
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SHAPIRO, RAYMOND MARC.
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Contributor
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Stanley D. Glick
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Date
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1986
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, Neuroscience
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Abstract
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The role of the dopaminergic nigro-striatal pathways in turning, or rotational, behavior in rats has been studied since the mid-1960s when it became clear that dysfunction in this system was related to the clinical manifestations of Parkinson's Disease in humans.;In this thesis, the combined use of biochemical, anatomical, and behavioral techniques resulted in the development of a more complex model of turning behavior than the one that is currently accepted. Using the Vmax for the dopamine uptake in vitro as a measure of dopaminergic nerve terminal density in the two striata, two groups of rats were identified on the basis of their spontaneous nocturnal rotational behavior. One group circles predominantly away from the side containing the striatum with the greater dopaminergic innervation, and the other circled predominantly towards the side containing the striatum with the greater dopaminergic innervation; but for both groups, the amount of rotational behavior was correlated with the size of the innervation asymmetry. While the current model for rotational behavior might have predicted this correlation for the group that rotated away from the side with the greater dopaminergic innervation, there is at present no model that would have predicted the second correlation; thus, this second correlation was regarded as evidence implying the existence of another "kind," or population, of rat.;Subsequent experiments were designed to test the validity of the proposed two population model. Neurochemical, anatomical, and functional differences were found between the striata of the two proposed populations of rats. Evidence for anatomical differences between the two populations came from measurements of dissected striatal tissue weights, and from tracings of enlarged projections of coronal cross-sections through the striatum. Additional support for the proposed two population model came from the results of a study examining the behavioral effects of partial unilateral 60HDA-induced striatal dopamine depletions on the side towards which the rats normally turned. Although the neurochemical effects of the lesions were virtually identical in the two groups, two groups of responders were clearly identified: In one group, turning toward the lesioned site was increased compared to controls, and in the other group turning toward the lesioned side was unchanged or was actually decreased. (Abstract shortened with permission of author.).
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Biomedical Sciences
