THE SITE SPECIFIC EFFECTS OF MORPHINE AND AMPHETAMINE ON INTRACRANIAL SELF-STIMULATION BEHAVIORAL INTERACTIONS BETWEEN THE LOCUS COERULEUS AND OTHER CENTRAL REWARD LOCI.
Item
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Title
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THE SITE SPECIFIC EFFECTS OF MORPHINE AND AMPHETAMINE ON INTRACRANIAL SELF-STIMULATION BEHAVIORAL INTERACTIONS BETWEEN THE LOCUS COERULEUS AND OTHER CENTRAL REWARD LOCI.
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Identifier
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AAI8614677
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identifier
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8614677
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Creator
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GIMINO, FREDERICK A.
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Contributor
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Solomon S. Steiner
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Date
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1986
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Physiological
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Abstract
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Rats were implanted with pairs of stimulating electrodes aimed at various intracranial self-stimulation (ICSS) loci. After subjects demonstrated stabilized rates of lever pressing, they were administered a daily injection consisting of either low doses of morphine, the opiate antagonist naloxone, or morphine plus naloxone. Subjects received these drugs under two ICSS conditions. In one condition electrical stimulation was delivered solely to one ICSS area, while in a second condition the pulse pairs were "split" between both ICSS sites.;Response rates supported by stimulating the medial forebrain bundle (MFB), the locus coeruleus (LC), and the fields of Forel (FF) were increased when subjects were injected with morphine. Morphine injections had no significant effects on ICCS rates maintained by cru cerebri (CC) stimulation.;Naloxone decreased ICSS rates from MFB sites at all doses while this agent affected placements ventral to the mammillothalamic tract only at high doses.;The "split" pulse condition produced an interaction. Response rates in this condition were always greater in magnitude than the sum of ICSS rates obtained when each site was stimulated alone. Animals with electrodes in the LC and either the fields of Forel or the cru cerebri displayed directional interactions. These interactions were always greater in magnitude when the LC was stimulated first. Animals with implants in the locus coeruleus and the medial forebrain bundle displayed non-directional interactions.;Morphine produced a significant rate facilitation. This effect was not contingent on the order of site activation in the non-directional interactions. The directional interactions demonstrated a significantly greater effect when the locus coeruleus was stimulated first.;The d-isomer of amphetamine produced a significantly greater rate facilitations than did the l-isomer. The d-isomer was also equally effective in facilitating rates regardless of the order of site stimulation in the non-directional, but not the directional interaction. The l-isomer had no effect on interactions between the LC and the CC.;Clonidine decreased ICSS rates systematically from the LC and MFB, but not the FF or CC electrode sites. This drug also decreased rates in the non-directional interaction condition. Clonidine blocked morphine's rate facilitatory effects only when the LC was activated first.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
