EFFECTS OF LONG-TERM INGESTION OF ETHANOL ON SELECTED ASPECTS OF ETHANOL METABOLISM AND LIPOGENESIS IN MOUSE LIVER (ALCOHOLISM, MALIC ENZYME).
Item
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Title
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EFFECTS OF LONG-TERM INGESTION OF ETHANOL ON SELECTED ASPECTS OF ETHANOL METABOLISM AND LIPOGENESIS IN MOUSE LIVER (ALCOHOLISM, MALIC ENZYME).
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Identifier
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AAI8629746
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identifier
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8629746
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Creator
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STERN, ZEV.
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Contributor
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George H. Fried
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Date
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1986
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, General
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Abstract
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Mice of the C57B1/6J strain were fed a liquid diet in which 36% of the calories consisted of ethanol. Control mice were pair-fed a diet in which ethanol was isocalorically replaced by carbohydrate. Ethanol-fed mice developed fatty livers. Control, but not ethanol-fed mice, gained weight throughout the experiment. Ethanol-fed mice were depleted of hepatic glycogen. Activity of the microsomal ethanoloxidizing system (MEOS) tended to rise in ethanol-fed mice, but this increase did not reach the 5% level of significance. There was a highly significant decrease in activity of malic enzyme, an enzyme involved in the synthesis of fatty acids, in ethanol-fed mice. Activity of lactate dehydrogenase also declined in ethanol-fed mice, while activities of glucose-6-phosphate dehydrogenase and alphaglycerophosphate dehydrogenase did not change. It is suggested that the very low carbohydrate content, and the relatively high fat content, of the ethanol-containing diet, as well as ethanol itself, are involved in these metabolic alterations. It appears that, under these conditions, livers of ethanol-fed mice synthesize very little fatty acids de novo. This situation is contrasted with genetic obesity, which lipogenic enzyme activities are elevated in livers that are accumulating lipid.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Biology
