HIPPOCAMPAL UNIT ACTIVITY DURING WAKING AND SLEEPING BEHAVIORS.
Item
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Title
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HIPPOCAMPAL UNIT ACTIVITY DURING WAKING AND SLEEPING BEHAVIORS.
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Identifier
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AAI8713784
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identifier
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8713784
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Creator
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PAVLIDES, CONSTANTINE.
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Contributor
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Richard J. Bodnar
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Date
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1987
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, Neuroscience
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Abstract
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Rat hippocampal (CA1) complex spike (place) cells of freely behaving rats (8-arm maze) were recorded in pairs continuously during a number of waking (exploration (XPL) and still-alert) and sleeping behaviors (quiet-awake (QA), slow-wave (SWS), pre- rapid-eye movement (PREM) and rapid-eye-movement (REM) sleep). Pairs of units were selected that did not have overlapping place fields (PF). The rats were restricted from entering the place fields of both cells overnight and on the day of recording they were exposed to their diverse PF's independently and in a counterbalanced design. Following exposure of each cell to its PF, recording was made in the subsequent sleeping episodes and the firing characteristics of both cells were analyzed.;Following exposure, significant increases in the spiking activity of the exposed cell were observed in the subsequent sleeping states, which were not evident in the unexposed cell. The increased activity was observed in the rate of firing (spikes/sec.), the number of spikes within a burst, as well as the number of bursts displaying 2-4 msec. interspike intervals (ISI).;In a second, descriptive experiment, the firing characteristics of hippocampal (CA1 and CA3) place cells were analyzed during similar sleeping and waking behaviors as in the first study. Higher overall firing rates were observed in the CA3 than in the CA1 field. The majority of CA1 cells also fired at higher rates in SWS than in REM sleep, in contrast to CA3 cells which fired at higher rates in REM than SWS. Both higher bursting and greater numbers of spikes within a burst were detected in CA3 than in CA1. Significantly longer bursts were also seen in QA and pre-REM. Lower ISI's (for spikes within a burst) were found in the CA1 than the CA3 hippocampal field, and also during REM and XPL.;The findings suggest that neuronal activity of hippocampal place cells in the awake states may influence the firing characteristics of these cells in subsequent sleep episodes. The increased firing rates along with the greater number of spikes and the shorter ISI's within the burst, following exposure to a cell's place field, may speak for possible information processing occurring during sleep.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology
