MEMORY DYSFUNCTION IN ALZHEIMER'S DISEASE AND ITS RELATIONSHIP TO BRAIN METABOLISM AS MEASURED BY POSITRON EMISSION TOMOGRAPHY.
Item
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Title
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MEMORY DYSFUNCTION IN ALZHEIMER'S DISEASE AND ITS RELATIONSHIP TO BRAIN METABOLISM AS MEASURED BY POSITRON EMISSION TOMOGRAPHY.
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Identifier
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AAI8801740
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identifier
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8801740
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Creator
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MILLER, JEFFREY DREW.
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Contributor
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Max Pollack
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Date
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1987
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Psychobiology
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Abstract
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Elderly controls and probable Alzheimer's disease (AD) patients underwent serial positron emission tomography (PET) studies during a baseline condition and while performing a verbal recognition memory task. A differential metabolic response specific to the temporal lobes was found. In all seven AD patients a greater proportion of the total temporal lobe activity favored the right during the memory condition when compared to baseline. Five out of seven controls showed the opposite effect; a task-related lateral asymmetry of activity that favored the left. Baseline regional metabolic rates were less useful than the memory challenge metabolic rates in differentiating patients from controls. These results suggest that the observed memory processing deficit in AD is related to a temporal lobe metabolic abnormality.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
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Program
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Psychology