Investigation of the role of physiological indices as predictors of sodium lactate response.
Item
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Title
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Investigation of the role of physiological indices as predictors of sodium lactate response.
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Identifier
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AAI8820881
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identifier
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8820881
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Creator
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Murphy, Patrick Michael.
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Contributor
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Adviser: Solomon Steiner
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Date
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1988
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Clinical
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Abstract
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There is a steady increase in the number of investigators who use physiological stimuli to induce an anxiety or panic response. In addition, there has been prolification of criteria set to identify the response. The purpose of the experiments described here was to employ a well standardized method of eliciting a report of panic and to depict a model for interpretation of physiological data as its' predictor. Subjects who report spontaneously occurring attacks reliably report similar response to the infusion of Sodium Lactate. The reliability of this physiological challenge test should allow for greater standardization in the laboratory description of the actual physiological events occurring during the spontaneous attacks.;These experiments attempt to ascertain the pattern of physiological response relative to the dose of lactate received by those who do respond. All subjects included in these experiments reported a response which they rated as significantly similar to their naturally occurring attacks.;The first experiment attempts to correlate individual response systems with the subjects' statement that they are experiencing panic. The peak respiratory rate occurred within fifteen seconds of response in all cases. The peak heart rate rise of 20 beats occurs within thirty seconds of response. Minute ventilation rose an average of 2.0 liters within sixty seconds of response. Skin conductance level rose sharply in half the cases and dropped sharply in the other half following lactate onset.;The second experiment is based on the post hoc definition of two subgroups. Those who responded in the first ten minutes and those who responded in the second ten minutes. Time was divided into protocoled ten minute epochs. Within each epoch, group means were used to evaluate the probability that the distributions were significantly different.;Skin conductance level was significantly lower for the early panickers prior to any invasive technique but switched during the second ten minutes. After the second ten minutes, skin conductance level was reduced from baseline for late responders but was increased for early group.;Respiratory frequency was the most significant discriminator between the two groups. With information on the minute ventilation, the results indicated that the early panickers were at their peak levels when they reported panic and the late panickers had passed their peak and had begun to decelerate.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
