The relationship of hippocampal theta rhythm and long-term potentiation.
Item
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Title
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The relationship of hippocampal theta rhythm and long-term potentiation.
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Identifier
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AAI8821086
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identifier
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8821086
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Creator
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Greenstein, Yoram J.
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Contributor
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Adviser: T. E. Frumkes
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Date
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1988
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, Neuroscience
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Abstract
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A leading candidate for a physiological model of memory is hippocampal Long-Term Potentiation (LTP), a long-term enhancement of synaptic efficacy that results from intense tetanic stimulation of hippocampal afferents. This synaptic enhancement can last for hours and even days. However, successful induction of LTP requires long trains of intense, tetanic stimuli that are not within the physiological range. Theta rhythm is a physiological phenomenon unique to the hippocampus. Hippocampal cells fire at theta rhythm periodicity (approximately 5-7 Hz) and are phase-locked to theta. The dissertation investigated the influence of stimulation of hippocampal afferents at theta rhythm frequency or stimulation at different phases of the rhythm upon the induction of LTP. Stimulating the perforant path at theta rhythm periodicity (200 msec inter-train interval; 5 Hz) preferentially induced LTP in the dentate gyrus, as compared to other inter-train intervals. Tetanizing the perforant path or Schaffer collaterals preferentially induced LTP in the dentate gyrus or CA1 area, respectively, if the stimulation was administered on the positive phase of the local theta rhythm. Stimulation on the negative phase caused no change or depressed the field potential. The data, taken in conjunction with studies of freely-moving rats suggest that theta rhythm plays a modulatory role in the induction of LTP, and suggests a mnemonic function for the rhythm.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
