Neuroanatomical and chemical changes within the nucleus accumbens paralleling patterns of behavioral activation in the developing rat.
Item
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Title
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Neuroanatomical and chemical changes within the nucleus accumbens paralleling patterns of behavioral activation in the developing rat.
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Identifier
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AAI8914752
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identifier
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8914752
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Creator
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Goodless, Nina Lauren.
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Contributor
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Adviser: Gordon A. Barr
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Date
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1988
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Physiological
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Abstract
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Various lines of evidence suggest that in the neonate certain stimuli elicit a constellation of oral-motor ingestive and non-ingestive responses, expressed as behavioral activation. The stimuli that activate pups include stroking, oral infusion of milk, and electrical stimulation of forebrain limbic structures. As the animal matures these stimuli become less reliable in eliciting these activating behaviors. The cause of the progressive decline in activation in older animals is not understood. Recent research from our laboratory and others have implicated a role for the Nucleus Accumbens (NAc) in behavioral activation. The present study explored the changing temporal and topographic patterns of stimulation-bound activity elicited by electrical stimulation of the NAc. Because the NAc is diversely innervated by several neurotransmitters systems, the second goal of the present study was to investigate the differential maturational patterns of the neuroanatomical and the neurochemical systems that may subserve the age related changes in behavioral activation.;This investigation explored the normal postnatal development of serotonin (5-HT), methionine enkephalin (met-Enk)- and {dollar}\gamma{dollar}-aminobutyric acid (GABA)-like immunoreactivity in tissue sections prepared using Sternberger's unlabeled antibody peroxidase-antiperoxidase technique. To relate the development of these neurotransmitters to morphological and metabolic characteristics of the NAc, the ontogenetic pattern of Nissl stained cells, Bodian silver stained fibers, and cytochrome C oxidase activity was examined.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
