The effects of benzodiazepines and beta-carbolines on rat pup ultrasonic isolation calls.

Title: The effects of benzodiazepines and beta-carbolines on rat pup ultrasonic isolation calls.
Identifier: AAI9000070
identifier: 9000070
Creator: Thom, Sara.
Contributor: Adviser: Myron Hofer
Date: 1989
Language: English
Publisher: City University of New York.
Subject: Psychology, Psychobiology | Psychology, Developmental | Psychology, Experimental
Abstract: The separation of rat pups from their mothers and littermates leads to increases in vocalization and locomotion. Chlordiazepoxide (1 + 3 mg/kg) reduces these vocalizations in one and two week old pups without reducing locomotor behavior. Substances active at the GABA-benzodiazepine receptor-chloride channel complex, pentylenetetrazol (15 + 30 mg/kg), methyl beta-carboline-3-carboxylate (3 + 9 mg/kg) and ethyl beta-carboline-3-carboxylate (1 microgram ICI) increase the number of vocalizations and decrease locomotor responses to isolation. These changes do not appear to be secondary to non-specific effect of thermoregulation or arousal. Temporal analysis of response changes and dose effects are reminiscent of adult rodent responses to conflict/punished response tests. These results are consistent with the hypothesis that rat pup separation distress behaviors in 2 week old pups may be mediated by the GABA-benzodiazepine receptor chloride channel complex.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.

Media: The effects of benzodiazepines and beta-carbolines on rat pup ultrasonic isolation calls.