The effect of dietary fat on the growth and metastasis of the 13762 mammary adenocarcinoma in the Fischer 344 rat.
Item
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Title
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The effect of dietary fat on the growth and metastasis of the 13762 mammary adenocarcinoma in the Fischer 344 rat.
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Identifier
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AAI9009748
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identifier
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9009748
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Creator
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Katz, Ellen Bennett.
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Contributor
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Adviser: Elizabeth S. Boylan
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Date
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1989
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, General
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Abstract
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The effect of both the quantity and quality of dietary fat on tumor growth and pulmonary metastasis (PM) from the 13762 mammary tumor (MT) was studied. Female Fischer 344 rats (8 week old virgins (YV), 10-12 month old retired breeders (RB)), pre-fed for 4 week high fat corn oil (23% w/w, HFCO) or low fat corn oil (5% w/w, LFCO) diets, were implanted subcutaneously with a 2 mm{dollar}\sp3{dollar} piece of 13762 MT. Six weeks later, necropsies were performed and total PM calculated. There was no difference in PM between the LFCO and HFCO YV groups. However, in the RB groups, both ovariectomized and intact, the HFCO groups had significantly more PM than the LFCO groups. The effect of reciprocal changes of diet at tumor implant was also studied. RB pre-fed either HFCO or LFCO were either kept on the same diet after tumor implant or changed to the other diet. In addition, rats maintained on Purina Rodent Chow were placed on HFCO or LFCO at tumor implant. Rats consuming the HFCO diet after tumor implant had significantly more PM than those receiving the LFCO diet. When the diets were initiated at tumor implant, there was no significant difference in PM between the HFCO and LFCO groups. Finally, the effect of different types of dietary fat was investigated. HFCO, LFCO, high and low fat olive oil (20% w/w, HFOO and 5% w/w, LFOO, mainly monounsaturated fat), and high fat beef tallow (20% w/w, HFBT, mainly saturated fat) were fed to RB 4 weeks prior to tumor implant. The HFCO animals had significantly more PM than the HFOO, FLOO, HFBT, and LFCO groups. In all the experiments, tumor growth did not vary significantly among the dietary groups. In summary, HFCO stimulates the growth of PM from the 13762 in RB. Changing the diets at tumor implant results in significantly more PM in pre-fed RB fed HFCO after tumor implant. Finally, HFCO stimulates the growth of PM in RB significantly more than HFOO, LFOO, HFBT, or LFCO.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
