Studies directed towards total synthesis of taxol. (I) An approach to the C-ring of taxol. (II) Studies on the synthesis of the A-ring of taxol.

Title: Studies directed towards total synthesis of taxol. (I) An approach to the C-ring of taxol. (II) Studies on the synthesis of the A-ring of taxol.
Identifier: AAI9020815
identifier: 9020815
Creator: Subasinghe, Kamani Rupika.
Contributor: Adviser: William F. Berkowitz
Date: 1990
Language: English
Publisher: City University of New York.
Subject: Chemistry, Organic | Chemistry, Pharmaceutical
Abstract: Taxol is a highly oxygenated tricyclic diterpenoid isolated from Taxus species. It exhibits unique biological activity.;Two key aspects in the synthesis of taxol have been investigated. In the first phase a C-ring synthon of taxol 109{dollar}\sp{lcub}\rm *{rcub}{dollar} was constructed by a Diels-Alder reaction. (See page 44 in dissertation for illustration.).;In the second phase cyclization studies have been carried out in development of an approach to construction of the A-ring of taxol. (Abstract shortened by author.).
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.

Media: Studies directed towards total synthesis of taxol. (I) An approach to the C-ring of taxol. (II) Studies on the synthesis of the A-ring of taxol.