Inhibitors of mitochondrial beta-oxidation and the mechanism of 3-hydroxyacyl-CoA epimerization.

Title: Inhibitors of mitochondrial beta-oxidation and the mechanism of 3-hydroxyacyl-CoA epimerization.
Identifier: AAI9029958
identifier: 9029958
Creator: Li, Jianxun.
Contributor: Adviser: Horst Schulz
Date: 1990
Language: English
Publisher: City University of New York.
Subject: Biology, General | Chemistry, Biochemistry | Health Sciences, Pharmacology
Abstract: In an attempt to develop a compound which would inhibit {dollar}\beta{dollar}-oxidation by specifically inactivating 3-ketoacyl-CoA thiolase (EC 2.3.1.16) in whole mitochondria, 4-bromo-2-octenoic acid was synthesized and studied.;The metabolism of 2-propylpentanoic acid (valproic acid), which is an antiepileptic drug but also causes inhibition of {dollar}\beta{dollar}-oxidation, was studied in rat liver mitochondria by spectrophotometric assays and high performance liquid chromatography.;The mechanism of 3-hydroxyacyl-CoA epimerase, which functions in the minor pathway of unsaturated fatty acid {dollar}\beta{dollar}-oxidation, was investigated. (Abstract shortened with permission of author.).
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.

Media: Inhibitors of mitochondrial beta-oxidation and the mechanism of 3-hydroxyacyl-CoA epimerization.