Flavor preferences and aversions conditioned by cholecystokinin.
Item
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Title
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Flavor preferences and aversions conditioned by cholecystokinin.
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Identifier
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AAI9029966
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identifier
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9029966
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Creator
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Perez, Catalina.
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Contributor
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Adviser: Anthony Sclafani
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Date
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1990
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Language
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English
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Publisher
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City University of New York.
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Subject
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Psychology, Experimental | Psychology, Physiological | Psychology, Psychobiology
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Abstract
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The ability of animals to avoid and approach foods based on the postingestive consequences of the foods is a well known phenomenon. In particular, studies using the Conditioned Flavor Preference (CFP) paradigm have demonstrated that rats learn preferences for arbitrary flavors associated with nutritive consequences. The present series of experiments examined whether cholecystokinin (CCK), an intestinal hormone that is a putative satiety agent, can mediate the CFPs produced by nutrients. Food-deprived rats were trained to consume a flavored solution (conditioned stimulus, CS+) which was paired with intraperitoneal injections of CCK octapeptide (unconditioned stimulus, US), and a different flavored solution (CS{dollar}-{dollar}) paired with saline injections. The conditioned response (CR), i.e., the flavor preference, was then measured in choice tests with the CS+ and CS{dollar}-{dollar} solutions. Several doses of CCK were investigated using test conditions and paradigms that were successful in producing flavor conditioning when a nutrient served as the US. In sham-feeding rats 2 and 4 {dollar}\mu{dollar}g/kg of CCK suppressed intake of flavored 8% Polycose but failed to condition a flavor preference. In rats real-feeding flavored saccharin solutions, CCK (0.125, 0.25, 0.5, 1, 2, and 4 {dollar}\mu{dollar}g/kg) suppressed intake in a dose-dependent manner, and conditioned both preferences and aversions depending on the dose. The two lower doses (0.125 and 0.25 {dollar}\mu{dollar}g/kg) failed to suppress CS+ intake during training and to condition either preferences or aversions during testing. At 0.5 and 1 {dollar}\mu{dollar}g/kg CCK had little effect on consumption but conditioned a flavor preference. At 2 {dollar}\mu{dollar}g/kg CCK suppressed CS+ intake but failed to produce flavor conditioning. The highest dose (4 {dollar}\mu{dollar}g/kg) inhibited saccharin intake in a potent manner and conditioned an aversion to the CS+ solution. Cholecystokinin (0.5 {dollar}\mu{dollar}g/kg) was also observed to condition a flavor preference in rats real-feeding restricted amounts of an 8% Polycose solution. These findings are consistent with the hypothesis that CCK may mediate at least in part the CFPs produced by nutrients.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
