Synthesis of novel muscarinic agonists.

Title: Synthesis of novel muscarinic agonists.
Identifier: AAI9130295
identifier: 9130295
Creator: Boulos, John.
Contributor: Adviser: Jerome Schulman
Date: 1991
Language: English
Publisher: City University of New York.
Subject: Chemistry, Organic
Abstract: We have synthesized a series of imidazole and oxazole-containing heterocyclic compounds, based upon a theoretical model of the structural requirements for muscarinic receptor activity. The compounds are intended as mimics of acetylcholine and other cholinergic agonists (cholinomimetics) at muscarinic cholinergic receptors in the brain and the peripheral nervous system. Muscarinic receptors are of importance in Alzheimer's disease and problems of intestinal mobility. Compounds which act selectively at these receptors could be desirable therapeutic agents as well as research probes of cholinergic pharmacology. Biological data have been obtained for some of these compounds.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.