Design and implementation of instrumentation for the observation of infrared (vibrational) circular dichroism from aqueous solutions.
Item
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Title
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Design and implementation of instrumentation for the observation of infrared (vibrational) circular dichroism from aqueous solutions.
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Identifier
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AAI9218247
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identifier
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9218247
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Creator
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Lee, Ou.
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Contributor
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Adviser: Max Diem
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Date
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1992
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical | Chemistry, Physical | Biophysics, General
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Abstract
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This dissertation reports the design and construction of two state-of-the-art dispersive instruments for the observation of Infrared (Vibrational) Circular Dichroism, their optimisation, as well as their superior performance. A discussion and comparison of result between the dispersive unit and Fourier transform infrared VCD describe the advantages and disadvantages of the respective technical approaches. The studies of alanyl peptides in aqueous solution demonstrate application aspects of VCD in attacking the difficult yet important problems of molecular conformation in aqueous solution, particularly for biological molecules. Furthermore, the exhibited structural sensitivity of VCD toward molecular chirality can find wide utilization in chiral analysis and determination, in such field as chiral synthesis and separation.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
