Computer modeling of blood flow through the heart during the complete cardiac cycle.
Item
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Title
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Computer modeling of blood flow through the heart during the complete cardiac cycle.
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Identifier
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AAI9304720
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identifier
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9304720
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Creator
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Printz, Beth Feller.
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Contributor
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Advisers: Louis Evan Teichholz | Charles S. Peskin
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Date
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1992
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Language
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English
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Publisher
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City University of New York.
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Subject
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Biology, Animal Physiology | Health Sciences, Medicine and Surgery | Engineering, Biomedical
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Abstract
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In this dissertation, a computer model of the left heart originally developed by Peskin and McQueen has been expanded in order to study blood flow through the heart during the complete cardiac cycle.;The original Peskin and McQueen computer model included the left atrium and ventricle separated by a mitral valve, but had no aortic valve. As such, only diastole and early systole could be studied. An ejecting aortic valve has been added to enable modeling of systolic and diastolic function; the model now is also capable of continuously simulating the beating heart. The shape of the heart has been changed to more closely reflect human cardiac geometry by using published data obtained from 2-D echocardiographic studies of the human heart.;The model has also been improved in a number of technical areas. The timestep has been refined to improve temporal resolution. One new display modality has been added: a simulation of color Doppler ultrasound. Volume conservation has been corrected through the introduction of a new formula for the divergence based on an interpolation scheme instead of a simple centered difference.;This expanded computational model of the left heart has been employed to explore a number of different aspects of cardiac physiology and pathophysiology. The effects of mitral apparatus geometry on mitral flow and leaflet motion have been investigated by varying the computational parameters that determine the initial size of the mitral leaflets, chordae tendineae and papillary muscle. This study provides mechanistic explanations for certain clinical observations, including the occurrence of early systolic mitral "regurgitation", the dissociation between mitral valve prolapse, redundant mitral leaflets, and true systolic back-flow, and changes in diastolic filling due to non-atrial causes. Aortic valve physiology also has been studied by changing the parameters that define the model natural aortic valve.;These applications illustrate just a few of the possible uses of this improved two dimensional cardiac model. Many additional clinical situations can be simulated by varying one or more of the model's parameters. Although limitations still remain, this model, which is capable of simulating one or more complete cardiac cycles, can be an important tool for understanding cardiac physiology and pathophysiology.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
