Initiation of messenger RNA decay in Bacillus subtilis.

Title: Initiation of messenger RNA decay in Bacillus subtilis.
Identifier: AAI9315458
identifier: 9315458
Creator: Di Mari, John Frank.
Contributor: Adviser: David H. Bechhofer
Date: 1993
Language: English
Publisher: City University of New York.
Subject: Biology, Molecular
Abstract: The initiation of messenger RNA (mRNA) decay can play an important role in the regulation of gene expression. To date, this process is poorly understood. Here I present evidence that strongly suggests that the general mechanism for the initiation of mRNA decay in Bacillus subtilis is inspection at the 5{dollar}\sp\prime{dollar} proximal region. This is demonstrated by the ability of the 5{dollar}\sp\prime{dollar} regulatory region of the ermC mRNA to confer stability to diverse downstream sequences. Although initiation of mRNA decay at the 5{dollar}\sp\prime{dollar} terminus appears to be a general mechanism, it is not obligatory since the initiation of decay can occur at other regions of the mRNA. The results of this thesis also demonstrate that segments of processed RNAs can remain stable after the initial degradative event indicating that the decay event can be blocked in Bacillus subtilis.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.