Electrochemistry in liquid microphase and simulation analysis of EC mechanism for vitamin B12 analogs.
Item
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Title
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Electrochemistry in liquid microphase and simulation analysis of EC mechanism for vitamin B12 analogs.
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Identifier
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AAI9315470
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identifier
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9315470
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Creator
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Huang, Qingdong.
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Contributor
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Advisers: David K. Gosser | Ronald L. Birke
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Date
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1993
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical | Chemistry, Biochemistry | Chemistry, Physical
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Abstract
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The thesis includes three parts of work related to electrochemistry. Part 1 describes the instrument and set-up, where one PC worked as waveform generator and another PC worked as oscilloscope interfaced with a home-built potentiostat. With this system, fast {dollar}k\sb{lcub}\rm chem{rcub}{dollar} in EC mechanism was measured. Part 2 describes electrochemical properties of solvent-electrolyte system with DMSO at low temperature below the freezing point. Based on electrochemical and ESR results, a theoretical model was developed to explain these phenomena as the existence of a liquid microphase. These electrochemical methods may open a new window to search for and optimize the components of cryopreservation systems with much better efficiency. Part 3 describes the electrochemical study of vitamin B{dollar}\sb{12}.{dollar} The electrochemical parameters of methylcobalamin were precisely measured by digital simulation - simplex curve fitting method. The solvent and temperature effects on {dollar}k\sb{lcub}\rm chem{rcub}{dollar} of methylcobalamin were investigated. The application region of simulation-fitting method in Butler-Volmer approach with fast {dollar}k\sb{lcub}\rm chem{rcub}{dollar} in EC mechanism was discussed. Electrochemical experiments of alkylcobalamin indicate that the spherical effect is the major effect on the E{dollar}\sp0\sp\prime{dollar} and {dollar}k\sb{lcub}\rm chem{rcub},{dollar} which favor the postulated mechanism of the inner spherical single electron transfer in biological processes.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
