Synthesis of archaebacterial tetraether lipid models.

Title: Synthesis of archaebacterial tetraether lipid models.
Identifier: AAI9325134
identifier: 9325134
Creator: Pan, Dongfeng.
Contributor: Adviser: Robert Bittman
Date: 1993
Language: English
Publisher: City University of New York.
Subject: Chemistry, Organic | Chemistry, Biochemistry
Abstract: Since it is difficult to obtain substantial amounts of archaebacterial tetraether lipids from natural sources, a synthetic strategy has been developed to prepare a simpler, acyclic, straight-chain tetraether model, 1,1{dollar}\sp\prime{dollar}-di-O-(1,32-dotriacontanediyl)-2,2{dollar}\sp\prime{dollar}-di-O-hexadecyl-3,3{dollar}\sp\prime{dollar}-di-O-benzyl-bis-glycerol 18. This coupling strategy may be applicable to the more difficult task of assembling the cyclic tetraether. The key steps of this synthetic strategy are (a) BF{dollar}\sb3{dollar}-catalyzed alcoholysis of glycidyl derivatives and (b) silver metal catalyzed Grignard reagent coupling method to connect two diether synthons to form the tetraether lipid.
Type: dissertation
Source: PQT Legacy CUNY.xlsx
degree: Ph.D.