Investigation of heterogeneous electron transfer on a mercury oblate spheroidal microelectrode and liquid chromatography with electrochemical detection for chloroquine and metal ions.
Item
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Title
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Investigation of heterogeneous electron transfer on a mercury oblate spheroidal microelectrode and liquid chromatography with electrochemical detection for chloroquine and metal ions.
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Identifier
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AAI9417473
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identifier
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9417473
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Creator
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Huang, Zuopeng.
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Contributor
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Adviser: Ronald L. Birke
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Date
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1994
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical
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Abstract
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A mercury microelectrode formed by electroreduction of mercury on an inlaid platinum microdisk is experimentally shown to be well modeled by oblate spheroidal geometry when the ratio of the semiminor axis to the semimajor axis of the protruding drop is less than one. The validity of the geometry is established by comparison of the experimentally determined coefficient in the steady state diffusion current equation with the theoretical value for oblate spheroidal geometry. Spherical cap geometry is also shown to be an equally valid geometric model; however, theoretical treatment for this system is more difficult. The theory of a quasi-reversible electrode process is developed and applied to the determination of the electrode process is developed and applied to the determination of the electrode parameters of the Ru(III)(NH{dollar}\sb3)\sb6{dollar}/Ru(II)(NH{dollar}\sb3)\sb6{dollar} electrode reaction on a mercury oblate spheroidal microelectrode. Results agree well with others found in the literature for the same process on a mercury electrode.;Liquid chromatography with a static mercury electrode has been studied to detect chloroquine based on the catalytic hydrogen wave. Both the electrochemical properties and optimal conditions of chromatography have been studied in this set of experiments. The results have shown this method can be used as an electrochemical detector for HPLC trace determination because of its high sensitivity and good reproducibility. Since nitrogenous compounds are widely used and many of these compounds have been reported to exhibit catalytic hydrogen wave at mercury electrode, the method should be quite general.;Liquid chromatography with thin-layer cell electrochemical detection has been investigated as a method for the simultaneous determination of copper, nickel, and cobalt in rock samples. This detection was based on formation, separation, and subsequent oxidation of dithiocarbamate complexes. The complex formation, reproducibility, interferences, and an analytical procedure for the detection are presented. Limits of detection of less than 1 ng can be obtained for all of these metals. The analysis results are in good agreement with the values from atomic absorption spectroscopy.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
