Sleep disruption in fatigued versus non-fatigued persons with multiple sclerosis.
Item
-
Title
-
Sleep disruption in fatigued versus non-fatigued persons with multiple sclerosis.
-
Identifier
-
AAI9432331
-
identifier
-
9432331
-
Creator
-
Caruso, Lauren S.
-
Contributor
-
Adviser: Arthur J. Spielman
-
Date
-
1994
-
Language
-
English
-
Publisher
-
City University of New York.
-
Subject
-
Psychology, Experimental | Psychology, Clinical | Psychology, Physiological
-
Abstract
-
Disabling fatigue, sleepiness, sleep changes, and sleep complaints are commonly reported by persons with MS. However, few studies have examined sleep and fatigue in the MS population. The present study examines MS related fatigue's relationship to sleepiness and sleep in 16 subjects with clinically definite MS, eight reporting fatigue (F) and eight not reporting fatigue (NF). Subjective measures of fatigue, sleep, sleepiness, depression, and mood scales as well as objective measures of sleepiness (Multiple Sleep Latency Test; MSLT) and sleep (nocturnal polysomnographic (NPSG) recordings) were used to test three hypotheses: (1) Persons with MS who complain of excessive fatigue will have higher indices of sleepiness and experience more sleep-disruptive behaviors and brain wave abnormalities during sleep than those persons with MS who do not report excessive fatigue; (2) Persons with MS will have more sleep-disruptive behaviors and brain wave abnormalities during nocturnal sleep than would be expected for persons without neurologic or psychiatric disorders; and (3) Persons with MS will manifest more variation in percentage of specific sleep stages and changes in sleep architecture than would be predicted by age and sex-appropriate norms for persons without neurological or psychiatric disorders.;Results indicated that in accordance with the first hypothesis, the F subjects reported significantly greater levels of sleepiness before and after nap (MSLT) opportunities. However, objective measures of sleepiness (MSLT), amounts of sleep disruptive behavior, and presence of brain wave abnormalities did not support a F versus NF group differentiation. In accordance with the second hypothesis, periodic limb movements (PLMs) and alpha EEG sleep were prevalent on NPSG recordings. However, PLMs and alpha EEG sleep were almost mutually exclusive, differentially affected stage two sleep, and were gender specific. In accordance with the third hypothesis, significant changes on NPSG recording were seen in percentage of REM sleep, sleep efficiency, and total sleep time. However, when Bonferroni corrections were applied to control for multiple tests of significance, only the presence of PLMs, alpha EEG sleep, and decreases in sleep efficiency remained significant.
-
Type
-
dissertation
-
Source
-
PQT Legacy CUNY.xlsx
-
degree
-
Ph.D.
