The primate cingulate cortex: Chemoarchitecture, projections to the primary motor cortex, and neuronal specialization.
Item
-
Title
-
The primate cingulate cortex: Chemoarchitecture, projections to the primary motor cortex, and neuronal specialization.
-
Identifier
-
AAI9618087
-
identifier
-
9618087
-
Creator
-
Nimchinsky, Esther A.
-
Contributor
-
Advisers: John H. Morrison | Patrick R. Hof
-
Date
-
1996
-
Language
-
English
-
Publisher
-
City University of New York.
-
Subject
-
Biology, Anatomy | Biology, Neuroscience
-
Abstract
-
The primate cingulate cortex is characterized by great anatomic and functional diversity. In an effort to further understand its anatomic organization and to relate its architecture to its described functional domains, the following set of experiments was designed. First, a chemoarchitectonic analysis of the cingulate cortex was undertaken in the macaque monkey, using neurofilament protein and calcium-binding proteins parvalbumin, calbindin and calretinin as cellular markers. Second, the analogous chemoarchitectonic analysis was performed of the cingulate cortex in the human, with special emphasis on features not found in the nonhuman primate. Third, a neurochemical study of two projections from the cingulate motor areas to the primary motor cortex was performed, using retrogradely transported dyes and neurofilament protein, a marker that emerged from the first two studies, to analyze at the cellular level the relationship between the neurochemical architecture of these areas and neurochemical characteristics of its corticocortical projection neurons. Lastly, the distribution of the dopamine D3 receptor protein was analyzed in the macaque monkey and rat cortex, with the aim of determining its usefulness as a specific marker for particular areas or projections within the cingulate cortex. The results of these studies demonstrated the chemoarchitectonic heterogeneity of the cingulate cortex, which is generally comparable in the macaque monkey and the human. However, the human cingulate cortex contains certain cell types not encountered in the macaque, such as spindle neurons and calretinin-containing pyramidal neurons in the anterior cingulate cortex. Neurofilament protein proved to be a useful marker for the cingulate motor areas in the macaque monkey, and the two cingulate motor projections had comparable proportions of neurofilament protein-containing neurons. Finally, the D3 receptor protein, at the light and confocal microscopic levels, had a nearly ubiquitous distribution in both the rat and macaque monkey, and was thus deemed not appropriate as a selective marker for certain areas or projections. The cingulate cortex in the human and nonhuman primate contains numerous discernable cortical areas whose functions are only beginning to be understood. Selective neurochemical markers and morphologic specializations may prove very useful in the further understanding of this cortical region.
-
Type
-
dissertation
-
Source
-
PQT Legacy CUNY.xlsx
-
degree
-
Ph.D.
