Computer-based techniques for cardiac mapping and electrogram analysis.
Item
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Title
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Computer-based techniques for cardiac mapping and electrogram analysis.
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Identifier
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AAI9707072
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identifier
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9707072
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Creator
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Caref, Edward Benjamin.
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Contributor
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Adviser: Thomas C. Wesselkamper
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Date
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1996
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Language
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English
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Publisher
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City University of New York.
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Subject
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Computer Science | Engineering, Biomedical | Health Sciences, Medicine and Surgery
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Abstract
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The integration of computer science and technology into biomedical science is required to investigate nearly all major aspects of basic and clinical research, including the area of cardiac electrophysiology. The isochronal activation mapping technique is most commonly used to understand the basic mechanisms of arrhythmias. There are, however, significant shortcomings toward utilizing this technique, including an adequate design and implementation of computer-based mapping systems to simultaneously record from multiple electrode sites, and objective, accurate analysis techniques applied to electrogram data. The latter is exacerbated when applied to data acquired from diseased cardiac tissue. Recent reports support the use of analytic statistical approaches to selected electrogram features, based on biophysical theory, which can provide more accurate and objective analysis of electrograms. The goals of this dissertation were to: (1) develop a computer-based mapping system that could perform state-of-the art mapping experiments in terms of data acquisition, accurate and reproducible analysis of waveforms, real-time interpretation of electrograms, ease of use, upgradability, and cost effectiveness; (2) develop a set of more strict guidelines for assigning activation time to both the unipolar and bipolar modes of electrogram recordings from normal cardiac epicardial sites; (3) develop a model that created a measurable technique for assessing the error rate of several electrogram features, and combine them into a discriminant function model to optimize the selection of electrogram features which minimize the error when compared to a standard of activation in an in vivo ischemic model of myocardial infarction; (4) determine the accuracy and usefulness of activation-recovery intervals obtained transmurally by extracellular unipolar electrograms in an in vivo model of polymorphic ventricular tachycardia.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
