Part I. Design and construction the step-scan Fourier transform vibrational circular dichroism. Part II. The conformation of small peptides in aqueous solution.
Item
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Title
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Part I. Design and construction the step-scan Fourier transform vibrational circular dichroism. Part II. The conformation of small peptides in aqueous solution.
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Identifier
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AAI9820548
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identifier
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9820548
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Creator
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Kocak, Ali.
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Contributor
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Adviser: Max Diem
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Date
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1998
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical | Chemistry, Physical | Chemistry, Biochemistry
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Abstract
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This dissertation consists of two parts: First part reports the design and construction of state-of-the-art interferometric instrument, "Fourier transform step-scan vibrational circular dichroism" for the observation of infrared (vibrational) circular dichroism (VCD), its optimization, as well as its performance. A discussion and compression of results between the fast-scan and step-scan interferometers describe the advantages of the step-scan interferometers in dynamic spectroscopy, where the lock-in amplifier need to subtract very small signals.;The second part of this dissertation is the application of the vibrational circular dichroism to study the structure of small peptides in aqueous solution. The studies of the effect of the temperature and the ionic strength on the structure of small peptides using VCD, demonstrate application of VCD in attacking the difficult yet important problems in the structure of small biological molecules in aqueous solution. This sensitivity towards the conformational changes in a very short time scale (vibrational time scale), makes the VCD if not the most important, a complementary technique to other techniques available to study the conformation of biological molecules.
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
