Novel uses of alpha-diimine ligands and their ruthenium(II) metal complexes.
Item
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Title
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Novel uses of alpha-diimine ligands and their ruthenium(II) metal complexes.
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Identifier
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AAI9997113
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identifier
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9997113
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Creator
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Morgan, Oma V.
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Contributor
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Adviser: A. D. Baker
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Date
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2001
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Language
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English
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Publisher
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City University of New York.
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Subject
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Chemistry, Analytical
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Abstract
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The alpha-diimine ligands pyridino[3,2-f]quinoxalino[2,3-h]quinoline (bppz), 11,12-dimethylpyridino[3,2-f]quinoxalino[2,3-h]quinoline (mbppz), benzo[f]pyridino[3,2-h]quinoline (bzp), pyridino[3,2-f]quinoxalino[2,3-h]quinoline (ippz), 2-(2-pyridyl)-1,3-oxazoline (pyoxazo), 4,4-dimethyl-2-(2-pyridyl)-1,3-oxazoline (dmpyoxazo) and 2-(1,3-oxazolin-2-yl)-1,3-oxazoline (bisoxazo) and their Ru(II) polypyridine complexes have been prepared and characterized. The ground and excited state acid-base properties of the complexes [Ru(bpy)2bppz] 2+ (pKa 1.89, (pKa* 2.62) (bpy = 2,2 '-bipyridine) and its methylated derivative [Ru(bpy)2mbppz] 2+ (pKa 1.85, (pKa* 3.18) have been measured.;A major focus of interest has been the interaction of mixed ligand complexes of the type [Ru(bpy)2L]2+ (L = bppz, mbppz, bzp, ippz, bisoxazo, pyoxazo, and dmpyoxzo) and also the tris complexes, [RuL 3]2+ (L = bzp, pyoxazo, and dmpyoxazo) with calf thymus DNA (B-DNA). Spectroscopic methods have been utilized to investigate the binding to DNA. Among these were absorption, emission, circular dichroism (CD), fluorescence quenching, fluorescence titrations (salt effect on binding), and equilibrium dialysis. For the complexes containing bisoxazo, pyoxazo, and dmpyoxazo fluorescence techniques were precluded since these compounds do not luminesce in aqueous solution or in the presence of DNA. Optical isomers of the Ru(II) complexes (referred to as delta and lambda) containing bppz, mbppz, bzp, and ippz which have been isolated. These enantiomers exhibit differential binding to DNA, and therefore provide valuable information on the overall binding to calf thymus DNA (B-DNA).
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Type
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dissertation
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Source
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PQT Legacy CUNY.xlsx
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degree
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Ph.D.
